Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Weniger BG[original query] |
---|
Safety, tolerability, and immunogenicity of inactivated trivalent seasonal influenza vaccine administered with a needle-free disposable-syringe jet injector
Simon JK , Carter M , Pasetti MF , Sztein MB , Kotloff KL , Weniger BG , Campbell JD , Levine MM . Vaccine 2011 29 (51) 9544-50 BACKGROUND: Jet injectors (JIs) avoid safety drawbacks of needle-syringe (N-S) while generating similar immune responses. A new generation of disposable-syringe jet injectors (DSJIs) overcomes the cross-contamination risk of multi-use-nozzle devices used in 20th-century campaigns. In the first study in humans, the newly-US-licensed LectraJet(R) model M3 RA DSJI was compared to N-S. METHODS: Sixty healthy adults received one 0.5mL intramuscular dose of the 2009-2010 seasonal, trivalent, inactivated influenza vaccine (TIV) in randomized, double-masked fashion by either DSJI (n=30) or N-S (n=30). Adverse reactions were monitored for 90 days after injection, and serologic responses assayed by hemagglutination inhibition (HI) at days 28 and 90. RESULTS: There were no related serious adverse events (SAEs), nor differing rates of unsolicited AEs between DSJI and N-S. Solicited erythema and induration occurred more often after DSJI, but were transient and well-tolerated; a trend was noted for fewer systemic reactions by DSJI. Pre-vaccination HI geometric mean titers (GMT) increased by 28 days for H1N1, H3N2, and B antigens by 13-, 14-, and 8-fold via DSJI, and by 7-, 10-, and 7-fold for N-S, respectively. No trending differences in GMT, seroconversion, or seroprotection were noted; sample sizes precluded non-inferiority assessment. CONCLUSIONS: DSJI delivery of TIV is well-tolerated and immunogenic. |
Needlestick injuries among sanitation workers in Mexico City
Thompson B , Moro PL , Hancy K , Ortega-Sanchez IR , Santos-Preciado JI , Franco-Paredes C , Weniger BG , Chen RT . Rev Panam Salud Publica 2010 27 (6) 467-468 Sanitation workers (SW) are exposed to a wide | range of biological, chemical, and physical hazards. | Needlestick injuries constitute a recognized physical | hazard, but few studies have been conducted to document the magnitude of the problem among SW. Contaminated sharp objects can transmit bloodborne | pathogens, such as human immunodeficiency (HIV), | hepatitis B (HBV), and hepatitis C (HCV) viruses. Needles and syringes contaminated with HBV and HCV | have been found in public recreational areas in South | London, United Kingdom (1). Although transmission | of such pathogens to sanitation workers and community members has not been demonstrated, there is the | potential for infection. We were not aware of any prior | study among SW in a developing country. Given this | lack of information, we conducted a survey of needlestick and sharps injuries among SW in Mexico City. | In July–August 2003, a non-random, convenience sample of 69 SW was selected from 13 of the 16 | Mexico City districts by finding and approaching sanitation vehicles during their daily rounds. Workers | were identified and interviewed on the street, while | working or during a break. Questionnaires determined | the frequency of sustaining a needlestick injury at | work, finding syringes with regular waste, vaccination | status, and health care-seeking practices. Epi InfoTM | Version 3.3.2 (Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America) was | used for data entry, descriptive epidemiology, and | analysis. |
- Page last reviewed:Feb 1, 2024
- Page last updated:May 13, 2024
- Content source:
- Powered by CDC PHGKB Infrastructure